Dynamic Optimization of Bioreactors: a Review

Dynamic Simulation and Control of Microbial Cell Population in Continuous Bioreactors

Bone Tissue Engineering: a Mini-Review

Despite advances in bone tissue engineering, auto grafts from intra-oral or extra-oral donor sites are still the gold standard for treatment of large craniomaxillofacial defects. Biomaterial development, application of growth factor, and stem cells, open new gateway to bone regeneration studies, but real translation from bench to bedside have not yet happened. In this review article, a number o...

Optimal Control of Fedbatch Bioreactors by Iterative Dynamic Programming

Obtaining the optimal control policy of a fedbatch bioreactor is a difficult task due to the low sensitivity of the feed rate on the objective function. In this work, iterative dynamic programming was selected for identification of optimal control policies of two fedbatch bioreactors for citric acid production. In the first application the raw material is molasses, and in the second is whey. Th...

Bioreactor-based bone tissue engineering: the influence of dynamic flow on osteoblast phenotypic expression and matrix mineralization.

An important issue in tissue engineering concerns the possibility of limited tissue ingrowth in tissue-engineered constructs because of insufficient nutrient transport. We report a dynamic flow culture system using high-aspect-ratio vessel rotating bioreactors and 3D scaffolds for culturing rat calvarial osteoblast cells. 3D scaffolds were designed by mixing lighter-than-water (density, <1g/ml)...

Combination of Electrochemical Processes with Membrane Bioreactors for Wastewater Treatment and Fouling Control: A Review

This paper provides a critical review about the integration of electrochemical processes into membrane bioreactors (MBR) in order to understand the influence of these processes on wastewater treatment performance and membrane fouling control. The integration can be realized either in an internal or an external configuration. Electrically enhanced membrane bioreactors or electro membrane bioreac...